Journal article

Using Polygenic Risk Scores to Refine Risk and Outcomes in High-grade Serous Ovarian Cancer in Australia.

Rachel Delahunty, S Sandun M Silva, Ahwan Pandey, Dale W Garsed, Jonathan Beesley, Sian Fereday, Nadia Traficante, Stuart Craig, Linh N Nguyen, Joy Hendley, Elizabeth L Christie, Penelope M Webb, Georgia Chenevix-Trench, David DL Bowtell, Kathryn Alsop, Madawa Jayawardana, Paul A James

Cancer Epidemiol Biomarkers Prev | Published : 2026

Open access

Abstract

BACKGROUND: Ovarian cancer is characterized by high mortality and lacks effective screening, making prevention critical. A polygenic risk score (PRS), which aggregates the effects of multiple common alleles, may capture a proportion of currently unexplained genetic risk. Although PRSs have been evaluated for risk prediction, their association with treatment response and survival remains unclear. This study assessed the utility of a PRS for predicting high-grade serous ovarian cancer (HGSOC) risk in an Australian population and its association with chemotherapy response and outcomes. METHODS: PRSs were calculated for 1,097 cases with HGSOC and 812 controls using data from Australian research ..

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Related Projects (7)

Grants

Awarded by Congressionally Directed Medical Research Programs (CDMRP)


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Tour de Cure (TDC)


Awarded by Victorian Cancer Agency (VCA)


Awarded by U.S. Army Materiel Command (AMC)